Technology

Accelerated Molecular Interactions

The PIXI platform combines a nanoporous capture substrate with electrically-driven analyte transport to eliminate the slow diffusive steps which limit the efficiency of traditional biomolecular interactions such as antigen-antibody binding assays.

Correlia PIXI cartridge integrates a proprietary nanomaterial to shrink interaction distances for target binding

elisa

Hour long incubation times required within a plate well

Traditional biomolecular reactions rely on slow and random “Brownian” motion across relatively large distances (mm) and volumes (~100uL) for ligand-partner interactions.

pixi

5 min sample transport across nanoporous substrate in a micro channel

Within the a PIXI cartridge, an electrical field drives analyte molecules through a porous gel that reduces the interaction distance between partner molecules.

For ELISA applications

Two types of PIXI kits are available for immunoassay applications:

1

Functionalize your cartridge

Any biotinylated ligand may be coated or “patterned” into each of the 96 devices within acustomizable PIXI cartridge

2

Accelerate your workflow

Electrically-Driven Mass Transport

Analytes are transported through electrophoresis, a well-established bioanalytical method that allows molecular transport rates to be carefully controlled through a power supply and buffer optimization.

Unparalleled Binding Efficiency

Molecules entering the ligand-functionalized zone are captured into the gel immediately. Subsequent introduction of the fluorescent detection reagent occurs on a similar rapid timescale. No incubation steps are required.

Technology Publication

Learn more about the PIXI’s underlying proprietary technology in our seminal paper: Araz, Apori, et al. “Microfluidic barcode assay for antibody-based confirmatory diagnostics”. Lab Chip. 2013